Hyperglycemia impairs left–right axis formation and thereby disturbs heart morphogenesis in mouse embryos
نویسندگان
چکیده
منابع مشابه
Hyperglycemia impairs left-right axis formation and thereby disturbs heart morphogenesis in mouse embryos.
Congenital heart defects with heterotaxia are associated with pregestational diabetes mellitus. To provide insight into the mechanisms underlying such diabetes-related heart defects, we examined the effects of high-glucose concentrations on formation of the left-right axis in mouse embryos. Expression of Pitx2, which plays a key role in left-right asymmetric morphogenesis and cardiac developmen...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2015
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1504529112